HPTLC and GC-MS finger-printing of two potential multifunctional siddha tailams: Mathan and maha megarajanga tailam.

The Siddha system of medicine is an ancient medical lineage that is practiced primarily in the southern part of India. Siddha system of medicine has been in practice for thousands of years with documented evidence dating back to the 6th century BCE. According to siddha system of medicine's basic fundamental principle, the human body is made up of 96 thathuvam (primary components), which encompass physical, physiological, psychological, and intellectual aspects. Medicine (marunthu) is classified as a wide range of internal and external medicines. The major components of its medical formulations include plant parts, minerals and animal products. Various methods were carried out for the purification process to eliminate the toxins. Choornam, Guligai, Tailam, Parpam, Chendooram, Kattu, Pasai and Poochu are the most common medicines used in Siddha system of medicine for the treatment of various diseases. The pathophysiological classification of diseases is elaborated in detail in the classical Siddha literature. Siddha system of medicine plays an important role in protecting people from diseases such as COVID-19 by providing immune-protecting and immune-boosting medicines in today's world. Mathan tailam and maha megarajanga tailam are the two unique preparations used widely for various skin diseases including chronic wounds and burns. Scientific validation of both medicines will help in understanding their effectiveness against a typical wound condition. In the present study physio-chemical and phytochemical, HPTLC, and GC-MS analyses were carried out and discussed in detail on the multifunctional properties exhibited in the patient communities.

In Silico Screening of Potential Phytocompounds from Several Herbs against SARS-CoV-2 Indian Delta Variant B.1.617.2 to Inhibit the Spike Glycoprotein Trimer

In October 2020, the SARS-CoV-2 B.1.617 lineage was discovered in India. It has since become a prominent variant in several Indian regions and 156 countries, including the United States of America. The lineage B.1.617.2 is termed the delta variant, harboring diverse spike mutations in the N-terminal domain (NTD) and the receptor-binding domain (RBD), which may heighten its immune evasion potentiality and cause it to be more transmissible than other variants. As a result, it has sparked substantial scientific investigation into the development of effective vaccinations and anti-viral drugs. Several efforts have been made to examine ancient medicinal herbs known for their health benefits and immune-boosting action against SARS-CoV-2, including repurposing existing FDA-approved anti-viral drugs. No efficient anti-viral drugs are available against the SARS-CoV-2 Indian delta variant B.1.617.2. In this study, efforts were made to shed light on the potential of 603 phytocompounds from 22 plant species to inhibit the Indian delta variant B.1.617.2. We also compared these compounds with the standard drug ceftriaxone, which was already suggested as a beneficial drug in COVID-19 treatment;these compounds were compared with other FDA-approved drugs: remdesivir, chloroquine, hydroxy-chloroquine, lopinavir, and ritonavir. From the analysis, the identified phytocompounds acteoside (-7.3 kcal/mol) and verbascoside (-7.1 kcal/mol), from the plants Clerodendrum serratum and Houttuynia cordata, evidenced a strong inhibitory effect against the mutated NTD (MT-NTD). In addition, the phytocompounds kanzonol V (-6.8 kcal/mol), progeldanamycin (-6.4 kcal/mol), and rhodoxanthin (-7.5 kcal/mol), from the plant Houttuynia cordata, manifested significant prohibition against RBD. Nevertheless, the standard drug, ceftriaxone, signals less inhibitory effect against MT-NTD and RBD with binding affinities of -6.3 kcal/mol and -6.5 kcal/mol, respectively. In this study, we also emphasized the pharmacological properties of the plants, which contain the screened phytocompounds. Our research could be used as a lead for future drug design to develop anti-viral drugs, as well as for preening the Siddha formulation to control the Indian delta variant B.1.617.2 and other future SARS-CoV-2 variants.

Indian Traditional Medicine for COVID-19

Background: A novel coronavirus COVID-19 outbreak causing infectious respiratory disorders. COVID-19 disease has no specific treatment. In traditional medicinal system, different formulations are available for infectious diseases. Objective(s): This review discusses the significance and utilization of Siddha and Ayurvedic herbal formulations for COVID-19 treatment and provides scientific information regarding the phytochem-istry and pharmacological profiles of Indian medicinal plants used in the formulation. Method(s): The information on medicine and medicinal plants was collected from research papers, review papers, and books available in several electronic databases, including Google Scholar, SpringerLink, and PubMed was explored as information sources. Result(s): Traditional medicinal plants are potentially used in formulations due to their inevitable therapeutic properties. Phytochemistry and pharmacological properties of medicinal plants used in the formulations served as scientific proof for traditional medicine. Conclusion(s): The present study explored the great importance of Siddha and Ayurvedic formulations for COVID-19 treatment. Further scientific investigations are required to explore these formulations as widely acceptable.Copyright © 2023 Bentham Science Publishers.

Simultaneous Quantification of Piperine, Vasicine and Eugenol in Kabasura Kudineer by HPTLC

Kabasura Kudineer is a polyherbal decoction of the Siddha medical system (an Indian system of medicine), traditionally used to cure fever, colds, coughs, and respiratory ailments. The government of India had recommended Kabasura Kudineer as one of many preventive/treatment measures for COVID-19. Kabasura Kudineer Choornam is an admixed coarse powder of 15 herbs and its decoction is Kabasura Kudineer. The chemical constituents in the 15 herbs used for the preparation of the Choornam are known but the constituents present in the Kabasura Kudineer (decoction) are unidentified. Piperine, vasicine and eugenol are known for their potent activity against respiratory tract infections;hence, they were selected as marker compounds. The present work was planned to simultaneously quantify piperine, vasicine and eugenol in Kabasura Kudineer by the HPTLC method. The optimised mobile phase was toluene: ethyl acetate: methanol: ammonia (5:9:3:0.5, v/v/v/v), and the scanning was carried out at 287 nm. The Rf values of piperine, vasicine and eugenol were found to be 0.70, 0.32 and 0.82, respectively. The linearity range of piperine and vasicine was 500-3000 ng spot-1 and it was 10-60 ng spot-1 for eugenol. The quantities of piperine, vasicine and eugenol in Kabasura Kudineer (100 mL) were 0.03, 0.056 and 0.035 % w/v, respectively. This developed method can be used to simultaneously quantify piperine, vasicine and eugenol in any polyherbal formulation.Copyright © 2023, Informatics Publishing Limited and Society for Biocontrol Advancement. All rights reserved.

Overview of COVID-19 Pandemic: Its Management and Prevention in Light of the Indian Traditional Medicine System

With the global death toll nearing 3.3 million, India being amongst the top 4 countries, the condition is more than fearsome. World Health Organization (WHO) recommends one doctor per 1000 population ratio, but India lags it by one doctor to 1456 people, which sets a lot of pressure on the healthcare system. Traditional remedies are becoming increasingly popular in India as a re-sult of the lack of a proper medical system. Due to the rich diversity of medicinal herbs and drugs, India has been managing health issues with its 5000 years old medication system. Amidst all this, the traditional medicine system has given relief to plenty of diseases and remains the primary de-fence system against COVID-19. Therefore, COVID-19 is also managed by its different medicinal systems, which are collectively known as the AYUSH regime. It had been a recognized system to tackle diseases in the past. In this mini-review, we performed a deep study of the Indian traditional medicine system in managing the COVID-19 situation.Copyright © 2023 Bentham Science Publishers.

Perception and Preference towards Siddha Medicines during Covid-19 in Tamil Nadu

The COVID-19 outbreak caused a huge loss of life, both for the victims and their families. It brought to a financial catastrophe that had unanticipatedly large proportions globally and ruined livelihoods. The Indian government has collaborated with the Ministry of Ayush to establish a number of policies and preventative actions to combat the COVID-19 epidemic. Patients have benefited from the use of these strategies in conquering the early stages of Corona virus infection. In light of COVID-19, the researcher is interested in learning how the general public in Tamil Nadu thinks about and favours Ayurvedic medicines. The researcher also wanted to know the respondents' preferences for the Ayurvedic medications they frequently used to treat different conditions. The results of the study were widely publicized throughout Tamil Nadu. The convenience sampling technique was used to gather the samples from the study area. The sample included 390 respondents. The research model was framed by the variables perception, usage, preference, and satisfaction. Four hypotheses were presented for this investigation. Primary data was acquired using a well-structured questionnaire. Variables pertaining to perception, usage, preference, and satisfaction were included in the questionnaire. This shows that consumption serves as a mediating variable in the relationship between consumer perception and desire for Ayurvedic medicines. Preference perception is significant at a level of 0.05. The research methodology and assumptions were tested and determined to be true, yet there is no significant relationship between utilisation and satisfaction. Copyright © 2023 Wolters Kluwer Medknow Publications. All rights reserved.

Health-related quality of life and associated factors among COVID-19 individuals managed with indian traditional medicine: A cross-sectional study from south India.

Introduction: Coronavirus disease-2019 (COVID-19) had a multidimensional impact on human life. It affects the health-related quality of life (HRQoL) which is a perceived measure of physical and mental health. We estimated the EuroQol utility value for COVID-19 and the associated factors for those managed at Siddha COVID care centres in Tamil Nadu. Methods: A cross-sectional study was conducted by a telephonic interview of 2000 randomly selected COVID-19 adults tested positive during June 2020 to Jan 2021. We collected sociodemographic, clinical and EQ-5D-5L profile. Mean EQ-5D-5L summary utility values and EQ-VAS scores were estimated. Multivariate regression was used to examine the factors associated with EQ-5D-5L. Study protocol was approved by the Institutional ethics committee of Government Siddha Medical College, Chennai (GSMC-CH-3401/ME-2/050/2021). The committee waived the written informed consent considering the pandemic situation of emerging infectious diseases. Results: We interviewed 1047 participants. Of the total 68% were males with the median age (IQR) of 38 (29-51) years. The mean EQ-5D-5L utility score and EQ-VAS scores are 0.98 ± 0.05 and 92.14 ± 0.39 respectively. COVID-19 asymptomatic group reported a mean utility score of 0.99 ± 0.03 which is relatively more than the symptomatic group (0.97 ± 0.06),. EQ-VAS score was also reported high among the asymptomatic (95.45 ± 5.95) than the symptomatic (91.40 ± 8.69COVID-19. Conclusion: The severity of illness and the comorbidity are significantly associated with a low HRQoL of COVID-19 patients.

Clinical outcomes among COVID-19 patients managed with modern and traditional Siddha medicine - A retrospective cohort study.

BACKGROUND: Kabasura Kudineer (KSK) is a Siddha polyherbal decoction recommended by the Ministry of AYUSH and the Tamil Nadu government to prevent and manage COVID-19 in India. OBJECTIVES: We aimed to determine the outcome of integrated therapy for COVID-19 using KSK in virologic clearance and length of hospital stay. MATERIALS AND METHODS: It was a single-centre, retrospective cohort study. We included the COVID-19 patients admitted to SRM Medical College Hospital and Research Centre, Chennai, during May-June 2020. KSK was administered along with the standard of care for all the patients. We collected data pertaining to demographic, clinical, and laboratory parameters and presented as frequencies and proportions. RESULTS: We collected 204 COVID-19 positive patients' data. The mean (SD) age was 39.5 (13.4) years with a range of 13-79. Majority of the patients were male (n = 157; 77%), 28% (n = 58) had any co-morbidities, and 61% (n = 131) had mild symptoms. Fever (n = 57; 27.9%) and cough (n = 53; 25.9%) were the commonly reported symptoms. Paracetamol (n = 135; 66.7%) and Zincovit (n = 197, 96.6%) were the commonly administered medicines along with KSK. About 74% of asymptomatic (n = 54) and 65% of mild symptomatic (n = 85) patients turned negative for COVID-19 in RT-PCR within 4-7 days. There was a significant difference in the blood parameters (p < 0.05) after the integrated treatment. CONCLUSION: The use of KSK with standard care of treatment in COVID-19 treatment had notable results in the duration taken for virologic clearance, thereby reducing the length of hospital stay and improvement in laboratory parameters.

Molecular Docking Study Of Shenbaga Poo Kuligai Against Sars Cov-2spike Proteinpdb 6vsband Human Ace -2 Receptor

As per world health organization report on 23 December 2022,there are 6.5 million confirmed cases of covid -19 which include 6.6 lacks deaths.[1] In current scenario new drug desining for covid -19 is essential and molecular docking study of spike protein SARS CoV-2 with human ACE2 molecules help to new Drug designing for corona virus.[2]According to siddha principle and medicine all disease can be treated successfully. The Research study of the Drug Shenbaga poo kuligai show good result in the treatment of SuzhiMantham[3]. The term SuzhiMantham in Siddha aspect, indicate the symptoms of Pain full and Spasmodic breathing[9] and the suzhimantham symptoms correlated to Acute Nasopharyngitis and WALRI in Children[6].The siddha Drug shenbaga poo kuligai will effectively treat the covid _ 19 Symptoms of Nasal discharge, Nasal obstruction, Fever, Difficulty in breathing, Rib Retraction, Cough, Wheezing, Pallorness of the body, Loss of appetite these are all also Suzhimantham symptoms[3-5] In the Molecular Docking study binding of phytocomponents of Shenbaga poo kuligai with the core amino acids of the target by forming hydrogen bond will hinder the function of the target COVID-19 spike glycoprotein with receptor-binding domain - PDB 6VSB is considered to be the potential target as it is highly essential to initiate the process of ACE2 recognition, binding and facilitate the entry of virus in to the host cell. Thereby phytocomponents Shenbaga poo kuligai that reveals potential binding with active amino acid on the receptor-binding domain of novel corona virus may act as a potential therapeutic agent for management of COVID-19 and related symptoms. All herbs in shenbaga poo kuligai is easily available and it was safe to covid patient. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Retrospective time to event analysis of integrated medicine treatment effect on mild symptomatic COVID19 patients in facility quarantine at Kallakurichi, Tamil Nadu

Background: This study has been conducted on confirmed COVID 19 positive patients (n = 55), who had come to Kallakurichi District of Tamilnadu state from one of the containment zones in Indian State of Maharashtra. Out of the 55, 8 (14.55%) patients were symptomatic and remaining 47 (85.45%) were asymptomatic patients. 47 patients who reached in their home land on 24th May and rest on 25th may 2020. All of them have been treated with integrated medicine treatment method. Materials and Methods: Everybody was quarantined from 27th may to 7th June 2020 at Mahabharathi Engineering College, Vasudevanur, Chinna salem Taluk, Kallakurichi District. Integrative Intervention Consisting of Vitamin C Tablet, Zinc tablet for 5 days, and Kabasura Kudineer 60 ml BD Before food for all days was the treatment given for all patients. Result: Among them, three of them had co -morbid conditions like diabetes and hypertension. 27.3% were female and 72.7% are male patients. Average age was 32.33 among the range of 14 to 65years. Conclusion: All patients including who has co-morbidity were completely relieved from the disease on the day of discharge. All symptomatic patients were asymptomatic with median time of 4 days IP admission.

Management of COVID - 19 with Siddha and Western Medicine - An Integrative Case Report.

Renaissance in acceptance of the Siddha system of medicine in all over India happened during the current scenario of coronavirus disease-2019 (COVID-19) pandemic. The classical texts of Siddha medicine contain descriptions of the symptoms of COVID-19 as a syndrome like definition that may be correlated with KabaSuram. A 49-year-old female residing at New Delhi who got COVID-19 positive with comorbidity of hypothyroidism treated successfully using an integrative treatment plan (Siddha and Allopathic) as per Government-mandated COVID-19 treatment guidelines. The patient developed symptoms such as fever, sore throat, cold, cough with expectoration, difficulty in breathing, chest congestion, and body ache. Initially the patient took Western Medicine (WM) for five days but the symptoms did not subside. After five days an integrated treatment including Siddha medicine (Internal and external medicines) initiated at In Patient ward, Safdarjung Hospital. The health of the patient improved within 3 days and all her symptoms got relieved within 10 days. After completion of treatment, she tested reverse transcription - polymerase chain reaction (RT-PCR) and it was negative on 14th day. Another patient who was admitted with her got COVID-19 positive turned negative only after 30 days as she missed the integrative medicine by probability. The reported case had a prospective follow-up for six months and found to be free of post-COVID complications. Since, this case report based on a single case which shows a positive outcome is incapable of generalizing the conclusion. Further suitable clinical trials need to be conducted to assess its efficacy. The status of the summary is reported as per CAse REport (CARE) guidelines.

Clinical profile of the patients at Siddha Covid Care Centre, Theni, Tamil Nadu, India - A cross-sectional study.

Introduction: The Indian Government issued various guidelines to the state government wherein introduced plan for setting up COVID care centres (CCC) to isolate and monitor asymptomatic and mild COVID-19 patients. The Government of Tamil Nadu, apart from CCC used the strength of traditional Siddha medicine, one of the Indian systems of medicine, by opening Siddha Covid Care Centres (SCCC) at various facilities like community hall, housing board homes, school and college hostels, across the state in 37 districts. Methods: As a cross-sectional study, we evaluated the clinical profile of the laboratory confirmed COVID-19 patient admitted in SCCC, Theni district, Tamil Nadu, India, which was opened on 8 May 2021. Results: During this month, 585 COVID-19 positive patients were admitted. Among them 60.9% were males, 39.1% were females. 40% of the admitted patients were in the age the group 31-50 years. 13% of the patient had at least one of the co-morbid condition and 80% were symptomatic with fever 40% and cough 36% as more common. Discussion: Patients were treated with the Siddha system of medicine adhering to the guidelines and were discharged after 10 days treatment. Nearly 4% who required further medical treatment observing their clinical condition and SpO2 levels were referred to the nearby medical college hospital. Conclusion: This study illustrated that SCCC offered appropriate clinical triaging and daily monitoring and hence it was considered as safe alternative to medical institutions during the pandemic.

Therapeutic Efficacy of Polyherbal Formulation Kabasura kudineer Against Common Viral Fevers-A Perspective Review

Background: COVID-19 viral infection is a worldwide pandemic that created a major concern regarding the need for a suitable drug candidate for viral infections. The entire scientific community is putting up their efforts and research to find a proper cure for this. The traditional Indian Siddha system of medicine is one of the oldest forms of medicine, which includes medicine, Varma, alchemy, yoga, and rejuvenation. Method(s): Kabasura kudineer is one of the Siddha herbal preparations that are being recommended by the State government of Tamilnadu, India, for protection against COVID-19. It is recommended due to its claims to have anti-viral properties and other numerous health benefits. Result(s): This article thoroughly examines the Kabasura kudineer, a polyherbal formulation comprising 15 powerful ancient Indian herbals that possess various potential phytochemicals providing numerous therapeutic activities. Also, the review highlights the most important therapeutic benefits of this formulation like anti-viral properties along with other activities such as im-munomodulatory, bronchodilatory, anti-asthmatic, etc., Conclusion(s): The role of Kabasura kudineer against viral diseases, especially the recent COVID-19, is tremendous, and there is a need to enhance further research on this powerful formulation to make it more efficient and useful to the entire people community. Copyright © 2022 Bentham Science Publishers.

Effectiveness of Siddha formulations for Sars CoV2 variants infection at home isolation in Chennai, Tamilnadu-A case series

As Sars CoV 2 infection was accountable for present global pandemic, many novel therapies and traditional medicines have been implied by various countries for the management and prevention of the spread. From the beginning, Corona virus mutation is also progressing with different variants. Delta variant was the most dreadful and contagious one, among the variants, which hospitalized more people. Now, Omicron is the new variant of concern announced by WHO in November 2021 which makes the disease more transmissible. In India, as the cases started rising from January 2022 by this new variant, various measures had been taken for the management of the disease. Traditional Siddha formulations were given for cases reported with positive Covid 19 infection, in home setting, at Chennai and the reports were shared here. Despite, genome sequencing is the precise diagnostic tool for variants detection, the cases reported here were in close possibility of omicron and mixed variants. Maha vasantha kusumakaram tablet a shastric higher order metallic preparation was proven to be effective with herbal preparations Thippili rasayanam, adathodai kudineer and Amukkara choornam. The patients recovered in a short span of time and the repeat Real time polymerase chain reaction (RTPCR) tested negative within 10 days. This was highly encouraging that Siddha medicines were proven to be effective in different variants of mutated Covid virus with no adverse effects and the medicines proved to be safe and effective by post-test of liver and renal parameters. Copyright © 2022, Indian Association of Biomedical Scientists. All rights reserved.

Public Health and the Politics of Knowledge: The Role of Traditional Medicine in the Management of COVID-19 in Two South Indian States

Public health discourse about COVID-19 pandemic has mostly been framed around biomedical interventions, although there is evidence of the effective use of traditional medicine (TM) to manage the pandemic by some Asian countries such as China, Thailand, Vietnam and India. This article aims to place on record the policy of medical pluralism in the two South Indian states of Tamil Nadu and Kerala in their respective deployment of Siddha and Ayurveda in the management of COVID-19. Based on interviews with physicians of TM and health administrators, press reports, social media posts and published research, this article reconstructs the crucial yet undocumented process of incorporating TM in the biomedicine-based health bureaucracy in Tamil Nadu and Kerala to deal with infectious fevers such as dengue and chikungunya in the past and COVID-19 in the present. It is our argument that those methods of TM which are safe and in long recent use could provide low-cost and accessible means of prevention and early treatment of infectious fevers. They have to be identified and subjected to further investigation as innovations in social medicine brought forth by the state and its officials and are different from the highly expensive projects of the corporate pharmaceutical sector. © 2022 SAGE Publications.

A case report of moderate COVID 19 patient managed through integrative approach (Siddha and conventional medicine).

Introduction: COVID 19 is a rapidly spreading disease with high mortality and morbidity all over the world which is caused by SARS-COV-2. Siddha system has various formulations with antiviral properties. The study is aimed at evaluating the efficacy of Siddha integrated with conventional medicine for effective management of COVID 19. Case summary: A 61 year old male patient diagnosed with COVID was brought in with the complaints of fever, cough, loss of smell, taste, tiredness and breathlessness after 7 days of infection. History revealed that he has not taken any treatment for the past 7 days and therefore presented with pneumonia at the time of consultation. Laboratory investigations showed Neutrophilia, Lymphocytopenia, raised NLR ratio, elevated CRP and D-Dimer. CT chest revealed CORADS-5 and severity score was 10/25. The patient was treated with Siddha medicine from 8 th Day. The patient had taken conventional treatment on 12 th day for 3 days only. Patient showed good improvement on 23 rd day and no adverse effect observed during the course of treatment. Conclusion: This case report demonstrates that moderate COVID 19 can be managed with integrative approach.

Acute Respiratory Distress Syndrome due to COVID-19 in India and efficacy of Indian Siddha drugs - A Trial of lopinavir-Ritonavir

Novel coronavirus pneumonia (COVID-19) is a respiratory infection caused by infecting lungs and respiratory pathways which has rapidly spread to 216 countries. It is causing serious harm to the world's entire population and a huge social burden, which can spread mainly by droplets produced during coughing and sneezing from animal to animal or human to human. There were no drugs or vaccines available as of May 2020. Though the severity and infectious behavior and mortality rate of COVID-19 led to the discovery of various vaccines and drugs that are available to control COVID-19 pandemic. India has two vaccines: Covishield and Covaxin approved by the Government of India on 2nd January 2021. Of this sudden and lethal disease, the traditional Indian siddha medicine was proficient as an alternative source, in performing differentiation with fewer side effects and better ability to prevent and control. In this article, we have comprehensively analyzed the case study and the efficacy of Indian Siddha medicine Kabasura Kudineer chooranam. Naturally occurring Indian Siddha medicinal (Kabasura Kudineer chooranam) compounds and its treatment as prevention measures so as to provide strategy and suggestions for the disease COVID-19 are discussed.

Safety and efficacy of a Siddha Medicine fixed regimen for the treatment of asymptomatic and mild COVID-19 patients.

Background: The Coronavirus disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a massive threat to public health worldwide. Siddha system of medicine is one of the traditional medicines of South India. The recommended formulations in Siddha Sasthric Medicines- Fixed Regimen (SSM-FiRe) are Amukkura tablets, Kaba Sura Kudineer (KSK) for asymptomatic COVID-19 positive (RT-PCR) patients, and Athimathuram tablets, Adathodai Manappagu syrup, Thippili Rasayanam, Brahmananda Bairavam tablet, and Notchi Kudineer for mild symptomatic patients. The core objective of the trial was to document the efficacy of SSM-FiRe in the prevention of asymptomatic and mild COVID-19 disease progression to the next level of severity, reduce the severity of symptoms and revert to RT-PCR Negative. Methods: An exploratory, prospective, open-labeled, single-arm, non-randomized trial was designed as per GCP guidelines to assess the efficacy of SSM-FiRe. Sixty RT-PCR positive participants who were asymptomatic or with mild COVID-19 symptoms were recruited for the study at the Siddha COVID Care Centre, Vyasarpadi, Chennai from June to August 2020. Nasal and oropharyngeal swab tests were performed on the 0, 7th, and 14th days. All participants were treated with SSM - FiRe regimen. All the participants were also assessed based on Siddha Yakkkaiyin Ilakkanam, which included Clinical symptoms and vitals. Laboratory investigations such as Haemogram, Liver Function Test, Renal Function Test, HbA1C, Electrolytes, Inflammatory markers, Cardiac profile, Immunoglobulins, and anti-SARS-CoV-2 antibody tests were performed. Results: 83% of COVID-19 patients turned RT-PCR negative on the 7th day and in most of the cases, symptoms were reduced within the first 5 days of admission. The RT-PCR cycle threshold (ct) value increased significantly (<0.001) after treatment and all the participants were RT-PCR negative, except one, who was positive even after 14 days. Anti-SARS-CoV-2 antibodies developed significantly (p-value - 0.006). LFT, RFT, CBC, Total proteins, and electrolytes continued to be in the normal range after treatment, indicating the safety of the intervention. Conclusion: Asymptomatic and mild COVID-19 disease can be well managed by SSM - FiRe treatment, Further studies could be taken up to strengthen the findings.

Postulation of Siddha tri-humoral vitiation in pathogenesis of novel Corona virus disease

Background: On March 12, 2020, WHO declared Novel Coronavirus disease as a pandemic outbreak all over the world. The outbreak had led the medical sector to a new platform, in the implementation of ancient knowledge of the Siddha medicine in treatment, management, and prevention of this prevailing pandemic. According to Siddha science, any vitiation in the life force is the main cause of diseases in human beings. pandemic diseases caused due to infectious microorganisms are called 'Kona' Noigal' in various Siddha literatures. Aim and objective: To classify the Novel Coronavirus disease based on the Siddha Humoural principles and to elicit the changes of Ninety-six Thatthuvam (Ninety - six basic principles), Uyir Thathukkal and Udal Thathukkal. Materials and methods: This study is accomplished mainly for literature research. Various Siddha texts such as Sattamuni gnanam, Agathiyar Gunavagadam, Agathiyar vallathi Naadi, Theraiyar Sekarappa, etc. were referred. Numerous research articles on COVID 19 were critically reviewed from Scopus, PubMed, Google Scholar, etc. Discussion: By critically reviewing the signs and symptoms of COVID-19 with Siddha science, the authors had thrown light especially on the involvement of all basic components of the Tri thodam particularly Mukkutram verupadu (Tri humoral vitiation) in eliciting the pathogenesis of the disease. Conclusion: In this scientific review, the authors have attempted to comprehend the pathogenesis of Novel coronavirus disease in the context of Siddha's basic principles.

Application of a Non-Linear multi-model Ayurveda Intervention in elderly COVID-19 patients- a retrospective case series.

The COVID-19 pandemic is ravaging the world, leaving the mainstream medical system handicapped with no proven treatment at one end and the ambiguities regarding the efficacies of vaccines at the other. The elderly population is at greater risk in terms of complications and death. The use of complementary and alternative medicine (CAM) against COVID-19 has already been documented in countries like China with a national participation rate of 90%. In this regard, the practice of CAM especially Ayurveda is relevant in India. The current report is a case series of 64 elderly COVID-19 patients managed through a Non-Linear multi-modal Ayurveda Intervention (NLMAI) via online consultation. NLMAI is a combination of herbal and herbo-mineral drug interventions, lifestyle modifications, and psychological support done in 2 phases. The post-management analysis revealed a mean duration of 11 symptoms of COVID-19 assessed through survival function as 0.577 days [SE=0.39] with a CI of 95% [0.500-0.653] which was considerably low when compared to global statistics. Moreover, none of the cases advanced to complications or death. Hence, novel approaches like NLMAI can be utilized to counter the gravity of the COVID-19 after scientific validation.